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Glial cells

Human iPSC-derived glial cells

Consistent, defined and scalable human iPSC-derived glial cell types for neurodegenerative disease research

Glial cells include astrocytes, microglia, oligodendrocytes, and associated precursor cells that enable the brain to function. Once known as nervenkitt (a German word meaning 鈥渘erve glue鈥�), glial cells are the 鈥済lue鈥� that holds the nervous system together by facilitating neuronal signalling, enabling tissue plasticity, providing neuronal support and axonal integrity, metabolism, and protecting neurons from would-be pathogens [1,2]. 

In recent years, a greater appreciation for the role of glial cells in neuronal homeostasis has helped expose potential therapeutic targets in neurodegenerative disease. Glial cells play a complex, enigmatic role in the development and progression of 础濒锄丑别颈尘别谤鈥檚 disease, Parkinson鈥檚 disease, and others. Many research projects are now focussing on understanding the therapeutic potential of targeting glial cells in neurodegenerative disease [2]. 

With access to a consistent and defined source of human glial cell types, researchers can build the complex, physiologically relevant glial cell culture models that are sorely needed in for drug discovery. Whether co-cultured with neurons, as part of a multi-cellular glial-neuronal culture, or used to build three-dimensional tissue models, ioCells are well suited for tissue and neurodegenerative disease modelling; for drug target identification and validation; as well as drug screening among many other uses. 

Take your research to the next level with our ioCells below.

ioWild Type Cells

ioAstrocytes ioWild Type Cells
ioAstrocytes cat no | ioEA1093
ioMicroglia | Female ioWild Type Cells
ioMicroglia | Female cat no | io1029
ioMicroglia | Male ioWild Type Cells
ioMicroglia | Male cat no | io1021
ioOligodendrocyte-like cells ioWild Type Cells
ioOligodendrocyte-like cells cat no | io1028
NEW! ioOPC-like cells ioWild Type Cells
NEW! ioOPC-like cells cat no | io1100

Engineered to meet your workflow with our toolkit of ioDisease Model Cells, ioTracker Cells and CRISPR-Ready ioCells

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CRISPRko-Ready ioOligodendrocyte-like cells CRISPR-Ready ioCells
CRISPRko-Ready ioOligodendrocyte-like cells cat no | io1095
GFP ioMicroglia | Male ioTracker Cells
GFP ioMicroglia | Male cat no | io1096
CRISPRko-Ready ioMicroglia Male CRISPR-Ready ioCells
CRISPRko-Ready ioMicroglia Male cat no | io1094
ioMicroglia P2RY12 null/WT ioDisease Model Cells
ioMicroglia P2RY12 null/WT cat no | io6015
ioMicroglia P2RY12 null/null ioDisease Model Cells
ioMicroglia P2RY12 null/null cat no | io6012
ioMicroglia TREM2 R47H/WT ioDisease Model Cells
ioMicroglia TREM2 R47H/WT cat no | io1038
ioMicroglia TREM2 R47H/WT ioDisease Model Cells
ioMicroglia TREM2 R47H/WT cat no | io1038
ioMicroglia APOE 4/3 C112R/WT ioDisease Model Cells
ioMicroglia APOE 4/3 C112R/WT cat no | io1033
ioMicroglia APOE 4/4 C112R/C112R ioDisease Model Cells
ioMicroglia APOE 4/4 C112R/C112R cat no | io1032
CRISPRa-Ready ioGlutamatergic Neurons CRISPR-Ready ioCells
CRISPRa-Ready ioGlutamatergic Neurons cat no | io1099
NEW! CRISPRa-Ready ioMicroglia Male CRISPR-Ready ioCells
NEW! CRISPRa-Ready ioMicroglia Male cat no | io1102
NEW! CRISPRi-Ready ioMicroglia Male CRISPR-Ready ioCells
NEW! CRISPRi-Ready ioMicroglia Male cat no | io1103

Human iPSC-based models of glial cells for studying neurodegenerative disease

Explore the implication of glial cells in neurodegenerative diseases in this webinar featuring , Senior Research Investigator, . 

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Product resources

Enhancement of MBP expression in human iPSC-derived oligodendrocyte-like cells by optimising db-cAMP concentration in media Technical note
Enhancement of MBP expression in human iPSC-derived oligodendrocyte-like cells by optimising db-cAMP concentration in media
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ioOligodendrocyte-like cells Brochure
ioOligodendrocyte-like cells
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ioAstrocytes Brochure
ioAstrocytes
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An iPSC-derived neuroinflammation/neurotoxicity in vitro model of neurons and glial cells Poster
An iPSC-derived neuroinflammation/neurotoxicity in vitro model of neurons and glial cells

Bsibsi et al.

Courtesy of Charles River Laboratories

2024

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Driving experimental reproducibility and lot-to-lot biological consistency in human iPSC-derived cells enabled by opti-ox technology Poster
Driving experimental reproducibility and lot-to-lot biological consistency in human iPSC-derived cells enabled by opti-ox technology

Newman et al.

糖心原创

2024

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Rapid and consistent generation of human iPSC-derived oligodendrocyte-like cells using opti-ox technology Poster
Rapid and consistent generation of human iPSC-derived oligodendrocyte-like cells using opti-ox technology

Herrera-Vaquero et al.

糖心原创

2024

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Establishment and validation of an in vitro co-culture model to study myelination using human iPSC-derived glutamatergic neurons and oligodendrocytes Poster
Establishment and validation of an in vitro co-culture model to study myelination using human iPSC-derived glutamatergic neurons and oligodendrocytes

Bsibsi et al.

Courtesy of Charles River Laboratories

2024

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In vitro model to study demyelinating disease using human OPC- and oligodendrocyte-like cells generated by deterministic cell programming Poster
In vitro model to study demyelinating disease using human OPC- and oligodendrocyte-like cells generated by deterministic cell programming

Veteleanu et al.

糖心原创

2025

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Reprogramming the stem cell for a new generation of cures Publication
Reprogramming the stem cell for a new generation of cures

Davenport A, Frolov T & Kotter M

Drug Discovery World

2020

 

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NRN1 as a therapeutic target for Alzheimer's disease Publication
NRN1 as a therapeutic target for Alzheimer's disease

Pugh DA, et al.

Alzheimer's & Dementia

2026

Using ioGlutamatergic Neurons and ioAstrocytes 

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Cellular reprogramming to enable the precise and scalable manufacturing of human cells for therapeutic applications Talk
Cellular reprogramming to enable the precise and scalable manufacturing of human cells for therapeutic applications

Dr Alex Davenport | Senior Scientist | 糖心原创

Talk at ELRIG Cell & Gene Therapy

2021

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Astrocytic calcium imaging 鈥� from mouse to human systems Talk
Astrocytic calcium imaging 鈥� from mouse to human systems

Jeremy Krohn | PhD Candidate | DZNE / Charit茅 University of Medicine

 

Human Cell Forum 2025
Session 1 Track 2 | From cells to systems: Building human iPSC-derived models of pain, neuromuscular junctions, and glial dynamics

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ioOligodendrocyte-like cells user manual | 糖心原创 User manual
ioOligodendrocyte-like cells

 糖心原创 

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ioAstrocytes user manual | 糖心原创 User manual
ioAstrocytes

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CRISPRko-Ready ioOligodendrocyte-like cells user manual | 糖心原创 User manual
CRISPRko-Ready ioOligodendrocyte-like cells
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How to culture ioAstrocytes Video tutorial
How to culture ioAstrocytes
Prachi Bhagwatwar鈥嬧�嬧�嬧�� | 鈥婻esearch Assistant | 糖心原创
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How to culture ioOligodendrocyte-like cells Video tutorial
How to culture ioOligodendrocyte-like cells
Prachi Bhagwatwar鈥嬧�嬧�嬧�� | 鈥婻esearch Assistant | 糖心原创
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Uncovering the Glioma Microenvironment With In Vitro Neuronal Models | 糖心原创 Webinar
Uncovering the Glioma Microenvironment With In Vitro Neuronal Models

Dr Brian Gill, MD | Assistant Professor of Neurological Surgery| Columbia University Irving Medical Center

Dr Tony Oosterveen | Principal Scientist and CNS Lead, Neurobiology | 糖心原创

 

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Exploring the critical roles of astrocytes in health and disease | 糖心原创 Webinar
Exploring the critical roles of astrocytes in health and disease
Jeremy Krohn | PhD candidate | German Center for Neurodegenerative Diseases (DZNE) Charit茅 Medical Neuroscience Graduate Program

Tom Brown | Senior Product Manager | 糖心原创
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Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease | 糖心原创 Webinar
Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease
Valentina Fossati, PhD | Senior Research Investigator | The New York Stem Cell Foundation

In锚s Ferreira | Senior Product Manager | 糖心原创
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Frequently Asked Questions (FAQs)

 

  • What is the role of glial cells in the nervous system?

Once described as nerve glue, glial cells, including astrocytes, microglia, and oligodendrocytes, were once only seen as the filler that supports and insulates neurons. Glial cells are now known to play a variety of critical roles in neuronal homeostasis, such as facilitating neuronal signalling, enabling tissue plasticity, and regulating metabolism. Growing recognition of their role in neuronal homeostasis has recently exposed them as potential therapeutic targets in neurodegenerative disease.

 

  • How do human iPSC-derived glial cells support neurodegenerative disease research?

Glial cells are essential for neuronal homeostasis and play a complex role in the progression of neurodegenerative diseases, such as 础濒锄丑别颈尘别谤鈥檚 and Parkinson鈥檚 disease. By providing a source of highly defined, consistent human glial cells at scale, ioCells enable scientists to build physiologically relevant models to investigate therapeutic targets and perform drug screening.

 

  • Which human iPSC-derived glial cell types are available within 糖心原创鈥檚 portfolio?

糖心原创's ioCells portfolio includes defined, consistent human iPSC-derived astrocytes, microglia, and OPC- and oligodendrocyte-like cells powered by opti-ox. These cryopreserved, post-mitotic cells are available as wild-type controls as well as genetically engineered disease models relevant to neurodegenerative disease research.

Additionally, we have developed a portfolio of CRISPR-Ready ioCells, in which wild-type ioCells have been engineered to include a Cas9 cassette, enabling quick and easy gene perturbations and CRISPR screens in physiologically relevant cells. We also offer a suite of ioTracker Cells, in which wild-type ioCells are engineered to express fluorescent tags for easy tracking and live imaging.

 

  • Can ioCells be used in multi-cell culture models?

ioCells glial cells are suitable for building complex, multi-cellular models for drug discovery and target validation. These human iPSC-derived cells can be co-cultured with neurons to create glial-neuronal cultures that enable the study of critical interactions, such as myelination or neuroinflammation, within a physiologically relevant human context.

 

  • What disease-specific models are available within the glial cell portfolio?

糖心原创鈥檚 glial cell portfolio includes human iPSC-derived disease models designed to support the study of genetic risk factors in neurodegeneration. Available cells include ioMicroglia expressing specific variants such as TREM2 R47H, P2RY12, and APOE, which allow scientists to compare functional differences between disease genotypes and their genetically matched wild-type controls.

References

1. J盲kel S, Dimou L. (2017) Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation. 2017 Feb 13;11:24. doi: . PMCID: PMC5303749  PMID:

2. Hanslik K, Marino K, Ulland T. (2021) Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease. . 2021 Aug 31;15:718324. doi: . PMCID: PMC8439422  PMID:

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