糖心原创

Human iPSC-derived muscle cells

Consistent, defined and scalable human iPSC-derived skeletal myocytes for musculoskeletal disorders (MSD) research

Significant advances are being made in the study of musculoskeletal disease. Where conditions like Duchenne muscular dystrophy (DMD) were once seen as untreatable, hope now swells as gene therapies advance into the market. Critical to the study and treatment of conditions like DMD is the use of physiologically relevant musculoskeletal disease models. As immortalised human muscle cell lines can be difficult to access, and animal myoblast cell lines are phenotypically distinct from their in vivo counterparts, many in the field are now turning to a more physiologically accurate source of cells: iPSC-derived myocytes [1].

糖心原创鈥檚 deterministic cell programming technology (known as 辞辫迟颈-辞虫鈩�) makes it possible to generate functional human skeletal muscle cells with unmatched lot-to-lot consistency from iPSCs on a nearly limitless scale (all without the challenges typically associated with myocyte differentiation). Both wild-type and disease-specific myocytes are readily available, enabling researchers to study skeletal myocytes in vitro with ever more translational power.

Leveraging genetically matched controls, human iPSC-derived skeletal myocytes containing DMD mutations can be used to screen prospective therapeutics, including exon-skipping therapies and other advanced drug modalities. 

Strengthen your research with 糖心原创鈥檚 human iPSC-derived skeletal myocytes.

Engineered to meet your workflow with our toolkit of ioWild Type Cells and ioDisease Model Cells

ioWild Type Cells

ioSkeletal Myocytes cat no | io1002

ioDisease Model Cells

ioSkeletal Myocytes DMD Exon 44 Deletion cat no | io1018

ioDisease Model Cells

ioSkeletal Myocytes DMD Exon 45 Deletion cat no | io6021

ioDisease Model Cells

ioSkeletal Myocytes DMD Exon 51 Deletion cat no | io6023

ioDisease Model Cells

ioSkeletal Myocytes DMD Exon 52 Deletion cat no | io1019

Driving a better understanding of musculoskeletal disease

, Director of Research in Genetics of Rare Neurological Disorders at the discusses the mechanical and metabolic roles of myocytes in health and disease, experimental limitations and new opportunities offered by consistent, scalable human myocytes for muscle research and disease modelling.

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Brochure

ioSkeletal Myocytes

糖心原创

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Poster

Stimulating 3D Skeletal Muscle Microtissues in a Novel Perfusable Microphysiological System with Integrated Electrodes

Dr Mitchell Han

Bi/ond

2023

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Poster

Generation of human iPSC-derived Duchenne muscular dystrophy skeletal myocytes suitable for 3D functional studies and investigating methods for dystrophin restoration

Bernard, et al

糖心原创

2024

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Publication

Functional neurological restoration of amputated peripheral nerve using biohybrid regenerative bioelectronics

Rochford and Carnicer-Lombarte et al.

Science Advances

2023

Featuring enabled skeletal myocytes iPS cell line

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Talk

Using human iPSC-derived ioSkeletal Myocytes and ioMotor Neurons to model complex neuromuscular systems in vitro

Dr Grace Cooper | Senior Scientist | 糖心原创

 

Human Cell Forum 2025
Session 1 Track 2 | From cells to systems: Building human iPSC-derived models of pain, neuromuscular junctions, and glial dynamics

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Talk

Toward clinical trial in a dish: harnessing iPSC models in drug discovery

Dr Sara Martin | Scientist | Axxam

 

Human Cell Forum 2025 
Session 3 | Making complex human biology compatible with modern drug discovery workflows

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User manual

ioSkeletal Myocytes and disease models user manual | 糖心原创

DOC-2849 3.0
糖心原创
2025

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Video

Introducing ioSkeletal Myocytes | Developing the next generation of human muscle cells

Dr Will Bernard | Director of Cell Type Development | 糖心原创

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Video tutorial

How to culture ioSkeletal Myocytes

Prachi Bhagwatwar鈥嬧�嬧�嬧�� | 鈥婻esearch Assistant | 糖心原创

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Webinar

Advances in cellular reprogramming: from stem cells to printed tissues | 糖心原创

Prof Hagan Bayley | University of Oxford
Dr Mark Kotter | Founder and CEO | 糖心原创

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Webinar

Research in Motion with ioSkeletal Myocytes | 糖心原创

Dr Luke Flatt | Senior Scientist | Charles River Laboratories

Dr Will Bernard | Senior Scientist | 糖心原创

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Webinar

Advancements in 3D modeling: Building mature, functional 3D skeletal muscle microtissues in vitro | 糖心原创

Dr Marieke Aarts | Principal Scientist | Bi/ond

Amanda Turner | Senior Product Manager | 糖心原创

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Protocol

mRNA transfection of ioSkeletal Myocytes | 糖心原创

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Protocol

Co-culturing ioSkeletal Myocytes and ioMotor Neurons | 糖心原创

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References

1. Danisovic L, Culenova M, Csobonyeiova M (2018) Induced Pluripotent Stem Cells for Duchenne Muscular Dystrophy Modeling and Therapy. . 2018 Dec 7;7(12):253. doi: . PMCID: PMC6315586  PMID:

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