糖心原创

Alzheimer鈥檚 is a genetic chronic neurodegenerative disease that typically begins around the age of 60 and progressively impairs cognition and language. A key common hallmark is the accumulation of plaques containing 尾-amyloid that leads to synaptic failure and, eventually, neuronal death. In recent years, reproducing and studying the mechanisms behind Alzheimer鈥檚 disease鈥檚 (AD) pathology and 尾-amyloid plaques-dependent degeneration have been facilitated by the advent of induced pluripotent stem cells (iPSCs).

This study describes a robust alzheimer鈥檚 disease in vitro model, in which treatment of iPSC-derived glutamatergic neurons with commercially available 尾-amyloid aggregates led to a quantifiable reduction of neuronal viability in line with patient pathology.