Publication
Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice
Read the publication to explore:
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The identification of RO48, a kinase inhibitor with advantageous polypharmacology (targeting ROCK2 and S6K1) that enhances intrinsic neurite growth
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Demonstration of corticospinal tract (CST) sprouting and regeneration across multiple independent mouse models of spinal cord injury
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Evidence of improved behavioral recovery in functional tasks, including rotarod, gridwalk, and pellet retrieval
- How ioGlutamatergic Neurons were used
Mah, et al
Experimental Neurology
2022