Publication
HNRNPH1 regulates the neuroprotective cold鈥恠hock protein RBM3 expression through poison exon exclusion
Read the publication to explore:
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A genome-wide CRISPR-Cas9 screen in human iPSC-derived neurons identifying HNRNPH1 as the primary regulator of RBM3 expression
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The discovery of a cold-dependent splicing mechanism that represses a poison exon to prevent nonsense-mediated decay
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How HNRNPH1 mediates thermosensitive exon skipping via interaction with a G-rich motif
Qiaojin Lin, et al
The EMBO Journal
2023
Featuring opti-ox powered hiPSC-derived glutamatergic neurons with constitutive expression of Cas9